CV

Chieh Hsu, PhD, FHEA

  • Qualified and experienced in university teaching in cell biology and molecular biology, including practical courses and seminar.
  • Solid and successful interdisciplinary research background in both cell biology and molecular systems biology;
  • Experienced in leading a research group and managing a laboratory.
  • 20+ years of wet lab experience involving advanced techniques e.g. TIRF microscopy, confocal microscopy, TEM and flow cytometry.
  • 10+ years of dry lab experience involving stochastic simulation and ODE modelling.
  • Excellent communicator: invited scientific presentations, lectures, publications and successful grant proposals.

Education

2018Postgraduate Certificate in Higher Education, University of Kent, England
2010PhD, Cell Biology, University of Göttingen, Germany
2006MSc, Biochemistry and Molecular Biology, University of Göttingen, Germany
2002BSc, Plant sciences, National Taiwan University, Taiwan

Selected work experience

Technical LeaderIn this position at Almac Group, I designed and incorporated advanced methods and techniques in molecular biology for biocatalytic applications. Duties for this R/D position included leading researching and prototyping technical innovation, tailoring projects for customers, and pitching ideas internally and externally.
Research Fellow
Principal Investigator
Based at University of Kent, I conducted independent research, teaching administrative duties, and coordinate inter-institutional projects between three universities. My research target was to bridge cell biology and molecular systems biology to establish a synthetic, protein based framework for quantitative cell biology. I employed recent techniques including dCas9-RNA based transcriptional control and optogenetics in the yeast systems. In addition, we recently discovered an interesting new structure in exosome biogenesis in cancer cells. My interests span fundamental and industrially relevant research topics in cell biology, control systems and biologics production.
Postdoctoral Research FellowAfter obtaining my PhD, I worked in the research group of Prof Attila Becskei at University of Zurich and University of Basel, expanding research capacity to molecular systems biology and acquired mathematical modelling as well as deep understanding of qRT-PCR for gene expression.

Selected Publications

2019
bioRxiv preprint
A novel exosome biogenesis mechanism: multivesicular structures budding and rupturing at the plasma membrane
2016
Cell reports
Protein dimerization generates bistability in positive feedback loops
2012
Nature communications
Stochastic signalling rewires the interaction map of a multiple feedback network during yeast evolution
2010
Journal of cell biology 
Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C
2008
Science
Ceramide triggers budding of exosome vesicles into multivesicular endosomes

Miscellaneous

2019Member of management committee for the UK, European cooperation in science and technologies (COST) Action: Non-conventional yeasts for the production of bioproducts.